Comprehensive Textbook of Pharmaceutical Chemistry and Pharmacology: From Principles to Practice

The fields of pharmaceutical chemistry and pharmacology are pivotal in the ongoing quest for new and improved therapeutic agents. “Comprehensive Textbook of Pharmaceutical Chemistry and Pharmacology: From Principles to Practice” aims to provide an extensive and integrated overview of these interconnected disciplines. This book is designed to cater to students, researchers, educators, and practitioners who seek a thorough understanding of drug development, mechanisms of action, and the therapeutic applications of both synthetic and natural compounds.
The first section of the book delves into the foundations of pharmaceutical chemistry. It starts with an introduction to its core principles and applications, followed by an exploration of drug design and development, from initial concept to clinical trials. Key topics such as synthetic methods, analytical techniques, pharmacokinetics, pharmacodynamics, and quality control are thoroughly covered. The section also addresses structure-activity relationship (SAR) studies, the role of computational chemistry in drug discovery, green chemistry practices, and regulatory aspects crucial for ensuring the safety and efficacy of pharmaceuticals.
In the second section, the focus shifts to pharmacology, offering a detailed examination of the mechanisms by which drugs exert their effects on the body. Chapters discuss drug receptors, signal transduction pathways, and the importance of pharmacogenomics and personalized medicine. We also cover adverse drug reactions, drug interactions, and the pharmacodynamics of drugs targeting various physiological systems, including the nervous and cardiovascular systems. Additionally, this section reviews anti-infective agents, cancer chemotherapy, and the pharmacological effects of herbal medicines.